An Evaluation of the Second Trimester Thyroid Function Test in Gestational Diabetes Mellitus: A Case-Control Study

Introduction: Gestational diabetes mellitus (GDM) is defined as glucose intolerance in a female with its onset or first recognition during pregnancy. Females GDM are at higher risk of developing antenatal complications like preeclampsia pregnancy and increased type 2 well cardiovascular disorders later their life. Maternal thyroid changes the second trimesters have been widely related to GDM. Hypothyroidism associated early late abortions, anaemia, gestational hypertension, placental abruption postpartum haemorrhage, impaired infant neurodevelopment, low birth weight. Objectives: This study aims compare function test (TFT) (serum fT3, fT4, TSH) peroxidase antibody (anti TPO) between non pregnant women trimester correlate adverse outcomes TFT women. Methods: A nested case-control was done Department Obstetrics Gynaecology, Endocrinology, Paediatrics, University College Medical Sciences, Guru Teg Bahadur (GTB) Hospital, Delhi. About 350 from 13 weeks till 28 period gestation were screened out which 40 selected after performing an oral tolerance (OGTT). anti TPO compared participants. Furthermore, various parameters sociodemographic profile, mode delivery, outcomes, maternal neonatal compared. Conclusion: The mean age found be more than values significantly lower In addition, (thyroid autoantibody) group aids insulin resistance. polyhydramnios, preterm labour, pregnancy-induced hypertension frequent group, but results statistically not significant. There incidence caesarean delivery group. Thus, we recommend implementation routine profile testing all females especially those who Our one few Indian studies evaluate association GDM, similar research larger sample size postnatal follow-up.